i can say a yes to this, my F1, coco has become more and more independent since she turned 6 months, i dont see it as a disadvantage, its just nature, up to age 4/5 months she would put up with being picked up and handelled all the time and loved it, now she is her own lady and its on her terms ,if, and when this happens, id say i get a once a fortnight cuddle from her now, compared to a once a night cuddle when she was a kitten, shes still by my side all day long, follows me round the house, and sleeps near me but she just doesn't want fussing now shes more independent. The only challanges this poses is visitors who want to pick her up etc, which isnt a problem once everyones educated who is a regular visitor to your house, otherwise they may get a bit of a F1 slap/hiss/growl from her the first time they try lol