I picked up some Nutricalm from my vet for Zuri's long car ride of 7 or more hours...I am testing it out, of course, before the trip. So I gave her some today and she has been calm, cool and collected for a few hours now (sleeping for about 2 hours)...and I only gave a fraction of the dose. I think this is the first time anything like this has worked and it is all natural - no drugs! YAY!!!