Well buying in to the ketamine thing or not is an individual preference but knowing the history and risk I would certainly not want to make a bet on coming out on the good end.
I have never had a problem with ketamine...it is not used as a single anesthetic agent, is used for many, many, many savannahs with absolutely no issues...when I see scientific proof that using Ketamine as a short acting agent with another agent is a major issue, then I might think otherwise.
I don't know what history you are speaking of. All I have heard are a handful of stories of problems after ketamine use, but do you really know what happened? None of us know if the cats were given an overdose by mistake, which I doubt would be admitted, if something else happened during surgery or if it was a true reaction...and that can happen with any drug...now what Brigitte is saying makes a lot of sense, as far as the Savannah being a lean-muscled cat, and the absorption may be greater because of the level of body fat vs. absorption. Say what you want, but I would rather my vet use ketamine and propofol, for instance, if that is what he is familiar with vs. a drug he is not familiar with, which will put a cat even more at risk...