Clostridium

[Brigitte Cowell]

Saunders Handbook of Veterinary Drugs says that it can be used orally in intestinal infections, but only gives dosage for cats for IV infusion.

 

[SV Dad]

Clostridium is an anaerobe. In humans, C. Diff can be a problem. Vanco is not absorbed orally, and it takes out C. Diff. That's why I'm asking Per if this might be an option. (My guess is the IV dose is for MRSA and other nasty bugs.)

 

[Brigitte Cowell]

Rascaldad, I have a doctorate in Microbiology, so yes I know what Clostridia are ;-)

Metronidazole is reported to work in most cases with C.difficile, even in humans, vancomycin generally is reserved when that fails. I think the key is to help the gut with offering beneficial bacteria to colonize the gut, restoring a healthy balance after any antibiotic treatment.

 

[SV Dad]

Good to know your background. We are having a challenge with C. Diff over here. Often we are double teaming metronidazole with the vanco. I'm not a fan of the therapy, but resistance seems to be evolving. (I don't want to get too off topic, but there seem to be other factors involved, PPI's.)
Where I am going with this, I am curious if this could be an option. I ran across some research recently that was disputing the probiotics efficacy. The problem is that it is in humans, and the cats certainly have different GI tract attributes.
This loose stool issue seems to come up a lot. I am starting to wonder if there is some genetic basis to this. I have had a lot of DSH's over the years and the loose stools haven't been a problem.
Lastly, I am wondering if clostridium takes off in cat's GI track more easily.

 

[Trish Allearz]

Rascaldad, I have a doctorate in Microbiology, so yes I know what Clostridia are ;-)

Metronidazole is reported to work in most cases with C.difficile, even in humans, vancomycin generally is reserved when that fails. I think the key is to help the gut with offering beneficial bacteria to colonize the gut, restoring a healthy balance after any antibiotic treatment.

So does amoxi not work at all with it, B? I thought I read that somewhere, but I could be wrong.

 

[SV Dad]

Trish, I was scratching my head on that one, too. Bridget, what say you?

 

[Trish Allearz]

http://www.vetinfo.com/treating-clostridium-in-dogs-with-amoxicillin.html

Is this a different clostridium?

Sent from my SGH-T769 using Tapatalk 2

 

[SV Dad]

Ok, that satisfies me. It should work. But now that information makes me think of another issue at play. Perhaps stress (new surroundings) in the young kittens affords the opportunity of the clostridium spores to activate.

 

[Trish Allearz]

Ok, that satisfies me. It should work. But now that information makes me think of another issue at play. Perhaps stress (new surroundings) in the young kittens affords the opportunity of the clostridium spores to activate.

LOL- I mean, sometimes I am a bit confused, but I THOUGHT I had read about amoxi and clostridium!

 

[Brigitte Cowell]

So does amoxi not work at all with it, B? I thought I read that somewhere, but I could be wrong.

I'm not sure where I said that amoxi doesn't work at all? What I said was that metronidazole was a better first option than vancomycin...?